Orlistate-the popular drug for treatment of obesity
Orlistat is a popular prescription medicine for treatment of obesity. This medicine is manufactured by F. Hoffmann-La Roche Ltd. of Switzerland. It is a very popular medicine used for treatment of obesity. Non-prescription Orlistat was approved in 2007, and by prescription in 1999 by the FDA. Prescription Orlistat is mostly available in the form of 120 mg tablets. It is sold under the trade name Xenical and it is available in several countries. On the other hand, the non-prescription product is available in the form of 60 mg tablets. These tablets are sold under the trade name Alli and they’re available in the U.S., U.K. and Canada. The Xenical is prescribed at a rate of one 120 mg capsule to be taken with liquid. The medicine is to be taken after every main meal containing some fat. Xenical can be taken up to 3 times a day, or up to 1 hour after a meal.
Benifits of Weight Loss
Fat is available in the form of fatty acids in the digestive tract. Absorption of fat happens only in the presence of lipases, which is an enzyme responsible for the breaking down of fat present in the body with the help of a chemical processes of fat metabolism. Orlistat is a lipase inhibitor and so it can decrease absorption of dietary fat because it inhibits gastrointestinal lipase function. The efficacy of Orlistat is moderate.
Data from clinical trials indicate:
1) Orlistat is capable of blocking fat aborption by 25 – 30% in case of a medically supervised diet, and so it can reduce the amount of calories consumed.
2) When orlistat is prescribed along with diet and exercise, the patients can lose 2-3 kilograms more than patients who are not using the medicinere over the course of 1 year.
Orlistat show some side effects, such as unpleasant gastrointestinal events, associated with elimination. The side effects intensity decreases over time. You can minimize the side effects by restricting the calories coming from fat to 30% in your diet. Some doctors say that the medicine should be used only on advice of a doctor, because it is a prescription weight loss medicine.
The medicine can result in medical problems like gallbladder problems, under-active thyroid, history of pancreatitis, diabetes, liver disease, and chronic malabsorption syndrome (nutrient absorption problems), if it is not used as per the instruction of the doctor. Some of the doctors say that the medicine should be used onlywith a physician-supervised diet. You should never give a medicine to anyone else. It is not a medicine meant for anyone under age 12. You should also keep it out of reach of children. Alli Orlistat also has some potential side effects. If you take a meal with more than 30 percent fat calories, when you are taking the medicine, you are more likely to suffer from problems like frequent bowl movements and gas with an oily discharge.Warning Orlistat can help you to lose weight moderately and it is clinically proven.